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POLE3

Gene

DNA polymerase epsilon 3, accessory subunit

HGNCHGNC:13546EnsemblENSG00000148229NCBI Gene54107
Locus: gene with protein productLocation: 9q32

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

DNA polymerase epsilon subunit 3Q9NRF9

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCHRAC17 · Ybl1 · p17 · CHARAC17 · CHRAC2
View full nomenclature history (12)
Alias symbolsCHRAC17, Ybl1, p17, CHARAC17, CHRAC2
Previous namespolymerase (DNA directed), epsilon 3 (p17 subunit), polymerase (DNA) epsilon 3, accessory subunit
Alias nameshistone fold protein CHRAC17, DNA polymerase epsilon p17 subunit, chromatin accessibility complex 17, arsenic transactivated protein, chromatin accessibility complex subunit 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DNA polymerasesATAC complexChromatin accessibility complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.