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POLR1A

Gene

RNA polymerase I subunit A

HGNCHGNC:17264EnsemblENSG00000068654NCBI Gene25885
Locus: gene with protein productLocation: 2p11.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

DNA-directed RNA polymerase I subunit RPA1O95602

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDKFZP586M0122 · FLJ21915 · RPO1-4 · RPA1 · RPA190
View full nomenclature history (6)
Alias symbolsDKFZP586M0122, FLJ21915, RPO1-4, RPA1, RPA190
Previous namespolymerase (RNA) I polypeptide A, 194kDa

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Benign prostatic hyperplasia
Neurodegenerative Diseases
Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

RNA polymerase subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.