POLR1E

Gene

RNA polymerase I subunit E

HGNCHGNC:17631 EnsemblENSG00000137054 NCBI Gene64425

Locus: gene with protein productLocation: 9p13.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPRAF1 · FLJ13390 · PAF53 · FLJ13970 · RPA49

View full nomenclature history (8)

Previous symbolsPRAF1

Alias symbolsFLJ13390, PAF53, FLJ13970, RPA49

Previous namespolymerase (RNA) I associated factor 1, polymerase (RNA) I polypeptide E, 53kDa

Alias namesRNA polymerase I associated factor 53

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Major depressive disorder

Pulmonary Disease, Chronic Obstructive

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

RNA polymerase subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.