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POMC

Gene

proopiomelanocortin

HGNCHGNC:9201EnsemblENSG00000115138NCBI Gene5443
Locus: gene with protein productLocation: 2p23.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Pro-opiomelanocortinP01189

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMSH · POC · CLIP · ACTH · NPP · LPH
View full nomenclature history (14)
Alias symbolsMSH, POC, CLIP, ACTH, NPP, LPH
Alias namesadrenocorticotropin, beta-lipotropin, alpha-melanocyte stimulating hormone, beta-melanocyte stimulating hormone, beta-endorphin, adrenocorticotropic hormone, opiomelanocortin prepropeptide, corticotropin

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Obesity disorder
Genetic Diseases, Inborn
Autoimmune Diseases
Hair color
Adrenal gland disorder
Cardiovascular Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Neuropeptides

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-06-27.
Open TargetsGene–disease associations from the Open Targets Platform.