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POU3F4

Gene

POU class 3 homeobox 4

HGNCHGNC:9217EnsemblENSG00000196767NCBI Gene5456
Locus: gene with protein productLocation: Xq21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDFN3 · BRN4 · OTF9 · DFNX2
View full nomenclature history (7)
Previous symbolsDFN3
Alias symbolsBRN4, OTF9, DFNX2
Previous namesPOU domain class 3, transcription factor 4
Alias namesbrain-4, Octamer-binding transcription factor 9

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Nonsyndromic genetic hearing loss
Non-syndromic genetic deafness
Hearing Loss

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

POU class homeoboxes and pseudogenes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.