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PPP3CA

Gene

protein phosphatase 3 catalytic subunit alpha

HGNCHGNC:9314EnsemblENSG00000138814NCBI Gene5530
Locus: gene with protein productLocation: 4q24

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Protein phosphatase 3 catalytic subunit alphaQ08209

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCALN · CALNA · CNA1 · PPP2B
View full nomenclature history (9)
Previous symbolsCALN, CALNA
Alias symbolsCNA1, PPP2B
Previous namesprotein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha), protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform, protein phosphatase 3, catalytic subunit, alpha isozyme
Alias namescalcineurin A alpha, protein phosphatase 2B, catalytic subunit, alpha isoform

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

early-infantile DEE
Diabetes Mellitus, Type 2
Genetic Diseases, Inborn
Obesity disorder
Genetic developmental and epileptic encephalopathy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Protein phosphatase catalytic subunitsMicroRNA protein coding host genesCalcineurin subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.