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PRKN

Gene

parkin RBR E3 ubiquitin protein ligase

HGNCHGNC:8607EnsemblENSG00000185345NCBI Gene5071
Locus: gene with protein productLocation: 6q26

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPARK2 · PDJ · AR-JP · parkin
View full nomenclature history (7)
Previous symbolsPARK2
Alias symbolsPDJ, AR-JP, parkin
Previous namesParkinson disease (autosomal recessive, juvenile) 2, parkin, parkinson protein 2, E3 ubiquitin protein ligase (parkin)
Alias namesE3 ubiquitin ligase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lung Neoplasms
Ovarian Neoplasms
Parkinson's Disease
Diabetes Mellitus
Diabetes Mellitus, Type 2

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteinsRBR E3 ubiquitin ligases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.