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PRNP

Gene

prion protein (Kanno blood group)

HGNCHGNC:9449EnsemblENSG00000171867NCBI Gene5621
Locus: gene with protein productLocation: 20p13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPRIP · GSS · CJD · CD230 · PRP · AltPrP
View full nomenclature history (12)
Previous symbolsPRIP, GSS, CJD
Alias symbolsCD230, PRP, AltPrP
Previous namesprion protein (p27-30), prion protein
Alias namesCreutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia, p27-30

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Dementia
Neurodegenerative Diseases
Genetic Diseases, Inborn
Prion Diseases
Cerebral Amyloid Angiopathy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Blood group antigensCD molecules

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-11-02.
Open TargetsGene–disease associations from the Open Targets Platform.