PROC

Gene

protein C, inactivator of coagulation factors Va and VIIIa

HGNCHGNC:9451 EnsemblENSG00000115718 NCBI Gene5624

Locus: gene with protein productLocation: 2q14.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

View full nomenclature history (3)

Previous namesprotein C (inactivator of coagulation factors Va and VIIIa)

Alias namesprepro-protein C, coagulation factor XIV

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

hereditary thrombophilia due to congenital protein C deficiency

Venous Thromboembolism

Venous Thrombosis

Thrombophilia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serine proteasesGla domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.