PSMA1

Gene

proteasome 20S subunit alpha 1

HGNCHGNC:9530 EnsemblENSG00000129084 NCBI Gene5682

Locus: gene with protein productLocation: 11p15.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Proteasome subunit alpha type-1P25786

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMGC22853 · HC2 · NU · PROS30 · MGC14542 · MGC14575 · MGC14751 · MGC1667 · MGC21459 · MGC23915

View full nomenclature history (13)

Alias symbolsMGC22853, HC2, NU, PROS30, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC23915

Previous namesproteasome subunit alpha 1, proteasome (prosome, macropain) subunit, alpha type, 1

Alias namesproteasome subunit α6

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Myeloma

Neoplasms

HIV Infections

Immunoglobulin Light-chain Amyloidosis

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Proteasome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.