Back to discover

PSMA3

Gene

proteasome 20S subunit alpha 3

HGNCHGNC:9532EnsemblENSG00000100567NCBI Gene5684
Locus: gene with protein productLocation: 14q23.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Proteasome subunit alpha type-3P25788

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHC8
View full nomenclature history (4)
Alias symbolsHC8
Previous namesproteasome (prosome, macropain) subunit, alpha type, 3, proteasome subunit alpha 3
Alias namesproteasome subunit α7

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Myeloma
Neoplasms
HIV Infections
Immunoglobulin Light-chain Amyloidosis
Neurodegenerative Diseases
Lymphoma, Large B-Cell, Diffuse

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Proteasome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.