PSMA6

Gene

proteasome 20S subunit alpha 6

HGNCHGNC:9535 EnsemblENSG00000100902 NCBI Gene5687

Locus: gene with protein productLocation: 14q13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Proteasome subunit alpha type-6P60900

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asIOTA · PROS27 · p27K · MGC22756 · MGC2333 · MGC23846

View full nomenclature history (9)

Alias symbolsIOTA, PROS27, p27K, MGC22756, MGC2333, MGC23846

Previous namesproteasome (prosome, macropain) subunit, alpha type, 6, proteasome subunit alpha 6

Alias namesproteasome subunit α1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Immunoglobulin Light-chain Amyloidosis

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Lymphoma, Large B-Cell, Diffuse

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Proteasome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.