PSMB5

Gene

proteasome 20S subunit beta 5

HGNCHGNC:9542 EnsemblENSG00000100804 NCBI Gene5693

Locus: gene with protein productLocation: 14q11.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Proteasome subunit beta type-5P28074

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMB1

View full nomenclature history (4)

Alias symbolsMB1

Previous namesproteasome (prosome, macropain) subunit, beta type, 5, proteasome subunit beta 5

Alias namesproteasome subunit X

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Myeloma

Lymphoma, Mantle-Cell

Neoplasms

Amyloidosis

HIV Infections

Immunoglobulin Light-chain Amyloidosis

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Lymphoma, Non-Hodgkin's

Lymphoma, Large B-Cell, Diffuse

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Proteasome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.