PSMB6

Gene

proteasome 20S subunit beta 6

HGNCHGNC:9543 EnsemblENSG00000142507 NCBI Gene5694

Locus: gene with protein productLocation: 17p13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Proteasome subunit beta type-6P28072

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asY · DELTA

View full nomenclature history (5)

Alias symbolsY, DELTA

Previous namesproteasome (prosome, macropain) subunit, beta type, 6, proteasome subunit beta 6

Alias namesproteasome subunit β1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Myeloma

Neoplasms

HIV Infections

Immunoglobulin Light-chain Amyloidosis

Neurodegenerative Diseases

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Lymphoma, Non-Hodgkin's

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Proteasome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.