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PSMB8

Gene

proteasome 20S subunit beta 8

HGNCHGNC:9545EnsemblENSG00000204264NCBI Gene5696
Locus: gene with protein productLocation: 6p21.32

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Proteasome subunit beta type-8P28062

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asLMP7 · RING10 · D6S216E · PSMB5i · beta5i
View full nomenclature history (10)
Previous symbolsLMP7
Alias symbolsRING10, D6S216E, PSMB5i, beta5i
Previous namesproteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7), large multifunctional peptidase 7, proteasome (prosome, macropain) subunit, beta type, 8, proteasome subunit beta 8
Alias namesproteasome subunit β5i

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Myeloma
Neoplasms
Immunoglobulin Light-chain Amyloidosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lymphoma, Non-Hodgkin's

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Proteasome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-06-07.
Open TargetsGene–disease associations from the Open Targets Platform.