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PSMC4

Gene

proteasome 26S subunit, ATPase 4

HGNCHGNC:9551EnsemblENSG00000013275NCBI Gene5704
Locus: gene with protein productLocation: 19q13.11-q13.13

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

26S proteasome regulatory subunit 6BP43686

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMIP224 · MGC8570 · S6 · TBP7 · MGC13687 · MGC23214 · TBP-7 · RPT3
View full nomenclature history (12)
Previous symbolsMIP224
Alias symbolsMGC8570, S6, TBP7, MGC13687, MGC23214, TBP-7, RPT3
Previous namesproteasome (prosome, macropain) 26S subunit, ATPase, 4
Alias namesprotease 26S subunit 6, Tat-binding protein 7, MB67 interacting protein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms
HIV Infections

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

AAA ATPasesProteasome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.