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PSMD3

Gene

proteasome 26S subunit, non-ATPase 3

HGNCHGNC:9560EnsemblENSG00000108344NCBI Gene5709
Locus: gene with protein productLocation: 17q21.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

26S proteasome non-ATPase regulatory subunit 3O43242

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTSTA2 · S3 · P58 · Rpn3
View full nomenclature history (6)
Previous symbolsTSTA2
Alias symbolsS3, P58, Rpn3
Previous namestissue specific transplantation antigen 2, proteasome (prosome, macropain) 26S subunit, non-ATPase, 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Myeloma
Neoplasms
HIV Infections
Neurodegenerative Diseases
Immunoglobulin Light-chain Amyloidosis
Atrial Fibrillation

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Proteasome

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.