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PTGIS

Gene

prostaglandin I2 synthase

HGNCHGNC:9603EnsemblENSG00000124212NCBI Gene5740
Locus: gene with protein productLocation: 20q13.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPGIS · CYP8A1
View full nomenclature history (5)
Alias symbolsPGIS, CYP8A1
Previous namesprostaglandin I2 (prostacyclin) synthase
Alias namescytochrome P450, family 8, subfamily A, polypeptide 1, prostacyclin synthase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Essential Hypertension
Infertility, Male
Schizophrenia
Neoplasms
Essential hypertension, genetic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Cytochrome P450 family 8Hydroperoxy icosatetraenoate dehydratases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.