PTGS2

Gene

prostaglandin-endoperoxide synthase 2

HGNCHGNC:9605 EnsemblENSG00000073756 NCBI Gene5743

Locus: gene with protein productLocation: 1q31.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Prostaglandin G/H synthase 2P35354

Protein · therapeutic target

Clinically validated target · 68 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCOX2

View full nomenclature history (4)

Alias symbolsCOX2

Previous namesprostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

Alias namesprostaglandin G/H synthase 2, cyclooxygenase 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Arthritis, Rheumatoid

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Prostaglandin-endoperoxide synthase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.