PTPA

Gene

protein phosphatase 2 phosphatase activator

HGNCHGNC:9308 EnsemblENSG00000119383 NCBI Gene5524

Locus: gene with protein productLocation: 9q34.11

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPPP2R4 · PR53

View full nomenclature history (7)

Previous symbolsPPP2R4

Alias symbolsPR53

Previous namesprotein phosphatase 2A, regulatory subunit B' (PR 53), protein phosphatase 2A activator, regulatory subunit 4, protein phosphatase 2 regulatory subunit 4

Alias namesphosphotyrosyl phosphatase activator, PP2A phosphatase activator

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Dermatitis, Atopic

Heart Septal Defects, Ventricular

Disorders of Excessive Somnolence

Neoplasms

Leukemia, Myeloid, Acute

Alzheimer's Disease

Parkinson's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Cyclophilin peptidylprolyl isomerasesProtein phosphatase 2 modulatory subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.