RAC1

Gene

Rac family small GTPase 1

HGNCHGNC:9801 EnsemblENSG00000136238 NCBI Gene5879

Locus: gene with protein productLocation: 7p22.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTC-25 · p21-Rac1 · Rac-1

View full nomenclature history (4)

Alias symbolsTC-25, p21-Rac1, Rac-1

Previous namesras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Melanoma

Cutaneous melanoma

Leishmaniasis, Cutaneous

Squamous Cell Carcinoma of Head and Neck

Genetic Diseases, Inborn

Neoplasms

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Rho family GTPasesReceptor ligands

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.