RAPH1

Gene

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

HGNCHGNC:14436 EnsemblENSG00000173166 NCBI Gene65059

Locus: gene with protein productLocation: 2q33.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asALS2CR9 · ALS2CR18 · KIAA1681

View full nomenclature history (5)

Previous symbolsALS2CR9, ALS2CR18

Alias symbolsKIAA1681

Previous namesamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 9

Alias namesamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 18

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Coronary Artery Disease

Familial prostate cancer

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.