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RBBP8

Gene

RB binding protein 8, endonuclease

HGNCHGNC:9891EnsemblENSG00000101773NCBI Gene5932
Locus: gene with protein productLocation: 18q11.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSCKL2 · CtIP · RIM · COM1
View full nomenclature history (8)
Previous symbolsSCKL2
Alias symbolsCtIP, RIM, COM1
Previous namesretinoblastoma-binding protein 8, Seckel syndrome 2, retinoblastoma binding protein 8
Alias namesCTBP-interacting protein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Seckel syndrome
Neoplasms
Genetic Diseases, Inborn
Microcephalic primordial dwarfism
Autosomal recessive primary microcephaly

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

BRCA1 C complexMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.