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RBX1

Gene

ring-box 1

HGNCHGNC:9928EnsemblENSG00000100387NCBI Gene9978
Locus: gene with protein productLocation: 22q13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

E3 ubiquitin-protein ligase RBX1P62877

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asROC1 · RNF75 · BA554C12.1
View full nomenclature history (4)
Alias symbolsROC1, RNF75, BA554C12.1
Alias namesregulator of cullins 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Multiple Myeloma
Myelodysplastic syndrome
Neoplasms
HIV Infections

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteinsSCF complex core subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.