Back to discover

RFFL

Gene

ring finger and FYVE like domain containing E3 ubiquitin protein ligase

HGNCHGNC:24821EnsemblENSG00000092871NCBI Gene117584
Locus: gene with protein productLocation: 17q12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asrififylin · fring · RNF189 · RNF34L · CARP2 · CARP-2
View full nomenclature history (8)
Alias symbolsrififylin, fring, RNF189, RNF34L, CARP2, CARP-2
Previous namesring finger and FYVE-like domain containing
Alias namescaspase 8 and 10 associated RING protein-2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Paroxysmal tachycardia
Hypertension, Portal

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.