RNASEL

Gene

ribonuclease L

HGNCHGNC:10050 EnsemblENSG00000135828 NCBI Gene6041

Locus: gene with protein productLocation: 1q25.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRNS4 · PRCA1

View full nomenclature history (4)

Previous symbolsRNS4, PRCA1

Previous namesprostate cancer 1, ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Familial prostate cancer

Ovarian Neoplasms

Prostatic Neoplasms

Multiple Sclerosis

Diabetes Mellitus, Type 2

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ankyrin repeat domain containingEndoribonucleases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.