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RXFP2

Gene

relaxin family peptide receptor 2

HGNCHGNC:17318EnsemblENSG00000133105NCBI Gene122042
Locus: gene with protein productLocation: 13q13.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asLGR8 · GREAT · GPR106 · INSL3R · RXFPR2
View full nomenclature history (7)
Previous symbolsLGR8
Alias symbolsGREAT, GPR106, INSL3R, RXFPR2
Previous namesleucine-rich repeat-containing G protein-coupled receptor 8, relaxin/insulin like family peptide receptor 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Cryptorchidism
Hypertension
Cardiovascular Diseases
Heart Failure
Hyperaldosteronism
Essential Hypertension
Hypokalemia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Relaxin family peptide receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.