SCN10A

Gene

sodium voltage-gated channel alpha subunit 10

HGNCHGNC:10582 EnsemblENSG00000185313 NCBI Gene6336

Locus: gene with protein productLocation: 3p22.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium channel protein type 10 subunit alphaQ9Y5Y9

Protein · therapeutic target

Clinically validated target · 60 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNav1.8 · hPN3 · SNS · PN3

View full nomenclature history (9)

Alias symbolsNav1.8, hPN3, SNS, PN3

Previous namessodium channel, voltage-gated, type X, alpha polypeptide, sodium channel, voltage-gated, type X, alpha subunit, sodium channel, voltage gated, type X alpha subunit

Alias namessensory neuron sodium channel, peripheral nerve sodium channel 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Episodic pain syndrome, familial, 2

Atrial Fibrillation

Arrhythmias, Cardiac

Sodium channelopathy-related small fiber neuropathy

Epilepsy

Major depressive disorder

Migraine Disorders

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Sodium voltage-gated channel alpha subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.