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SDHB

Gene

succinate dehydrogenase complex iron sulfur subunit B

HGNCHGNC:10681EnsemblENSG00000117118NCBI Gene6390
Locus: gene with protein productLocation: 1p36.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSDH · SDH1
View full nomenclature history (6)
Previous symbolsSDH, SDH1
Previous namessuccinate dehydrogenase complex, subunit B, iron sulfur (Ip), succinate dehydrogenase complex subunit B, iron sulfur (Ip)
Alias namesiron-sulfur subunit of complex II, succinate dehydrogenase [ubiquinone] iron-sulfur subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Pheochromocytoma
Gastrointestinal Stromal Tumors
Inherited cancer-predisposing syndrome
Neoplastic Syndromes, Hereditary
Paraganglioma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitochondrial complex II: succinate dehydrogenase subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.