SERPINA1

Gene

serpin family A member 1

HGNCHGNC:8941 EnsemblENSG00000197249 NCBI Gene5265

Locus: gene with protein productLocation: 14q32.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPI · AAT · A1A · PI1 · alpha-1-antitrypsin · A1AT · alpha1AT

View full nomenclature history (13)

Previous symbolsPI

Alias symbolsAAT, A1A, PI1, alpha-1-antitrypsin, A1AT, alpha1AT

Previous namesserine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Alias namesprotease inhibitor 1, anti-elastase, alpha-1 antitrypsin, alpha-1 proteinase inhibitor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Pulmonary Disease, Chronic Obstructive

Cholelithiasis

Pulmonary Emphysema

Liver Cirrhosis

Coronary Artery Disease

Liver Diseases

Gallstones

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serpin peptidase inhibitors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.