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SERPINB1

Gene

serpin family B member 1

HGNCHGNC:3311EnsemblENSG00000021355NCBI Gene1992
Locus: gene with protein productLocation: 6p25.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asELANH2 · EI · PI2 · LEI · MNEI
View full nomenclature history (10)
Previous symbolsELANH2
Alias symbolsEI, PI2, LEI, MNEI
Previous namesserine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1, serpin peptidase inhibitor, clade B (ovalbumin), member 1
Alias namesleukocyte elastase inhibitor, monocyte/neutrophil elastase inhibitor, anti-elastase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes Mellitus, Type 2
Neoplasms
Infections
Isolated agammaglobulinemia
Obesity disorder
Obesity due to melanocortin 4 receptor deficiency
Diabetes, Gestational
Autosomal agammaglobulinemia
Common variable immunodeficiency

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serpin peptidase inhibitors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.