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SETD2

Gene

SET domain containing 2, histone lysine methyltransferase

HGNCHGNC:18420EnsemblENSG00000181555NCBI Gene29072
Locus: gene with protein productLocation: 3p21.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHYPB · HIF-1 · KIAA1732 · FLJ23184 · KMT3A
View full nomenclature history (6)
Alias symbolsHYPB, HIF-1, KIAA1732, FLJ23184, KMT3A
Previous namesSET domain containing 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Renal Cell
Genetic Diseases, Inborn
Neurodegenerative Diseases
Adenocarcinoma of Lung
Leukemia, Lymphocytic, Chronic, B-Cell
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Histone lysine methyltransferasesSET domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-11-07.
Open TargetsGene–disease associations from the Open Targets Platform.