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SH2B2

Gene

SH2B adaptor protein 2

HGNCHGNC:17381EnsemblENSG00000160999NCBI Gene10603
Locus: gene with protein productLocation: 7q22.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAPS
View full nomenclature history (2)
Alias symbolsAPS
Alias namesadaptor protein with pleckstrin homology and src

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Dementia
Brain Diseases
Mental Disorders
Diabetes Mellitus, Type 2
Gastrointestinal disease
Pre-Eclampsia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingSH2 domain containingMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.