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SIGLEC8

Gene

sialic acid binding Ig like lectin 8

HGNCHGNC:10877EnsemblENSG00000105366NCBI Gene27181
Locus: gene with protein productLocation: 19q13.41

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSIGLEC-8 · SAF2 · SIGLEC8L · MGC59785
View full nomenclature history (5)
Alias symbolsSIGLEC-8, SAF2, SIGLEC8L, MGC59785
Previous namessialic acid binding Ig-like lectin 8

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Eosinophilic Esophagitis
Metabolic Syndrome
Alzheimer's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

V-set domain containingSialic acid binding Ig like lectins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-03-27.
Open TargetsGene–disease associations from the Open Targets Platform.