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SIX5

Gene

SIX homeobox 5

HGNCHGNC:10891EnsemblENSG00000177045NCBI Gene147912
Locus: gene with protein productLocation: 19q13.32

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDMAHP
View full nomenclature history (3)
Previous symbolsDMAHP
Previous namessine oculis homeobox (Drosophila) homolog 5, sine oculis homeobox homolog 5 (Drosophila)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Early-onset non-syndromic cataract
Total congenital cataract
Posterior polar cataract

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SINE class homeoboxes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.