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SLC12A1

Gene

solute carrier family 12 member 1

HGNCHGNC:10910EnsemblENSG00000074803NCBI Gene6557
Locus: gene with protein productLocation: 15q21.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Solute carrier family 12 member 1Q13621

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNKCC2 · CCC2 · BSC1 · BSC · BSC-1
View full nomenclature history (9)
Alias symbolsNKCC2, CCC2, BSC1, BSC, BSC-1
Previous namessolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Alias namesNa-K-2Cl cotransporter 2, bumetanide-sensitive cotransporter type 1, Kidney-specific Na-K-Cl symporter

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Bartter Syndrome
Nephrotic Syndrome
Hypertension
Heart Failure
Kidney Diseases
Liver Cirrhosis
Cardiovascular Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Solute carrier family 12

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.