SLC12A3

Gene

solute carrier family 12 member 3

HGNCHGNC:10912 EnsemblENSG00000070915 NCBI Gene6559

Locus: gene with protein productLocation: 16q13

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Solute carrier family 12 member 3P55017

Protein · therapeutic target

Clinically validated target · 13 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTSC · NCCT · NCC

View full nomenclature history (7)

Alias symbolsTSC, NCCT, NCC

Previous namessolute carrier family 12 (sodium/chloride transporter), member 3

Alias namesNa-Cl symporter, sodium-chloride co-transporter, Thiazide-sensitive sodium-chloride cotransporter

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Gitelman Syndrome

Hypertension

Nephrotic Syndrome

Kidney Failure, Chronic

Heart Failure

Myocardial Infarction

Cardiovascular Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MicroRNA protein coding host genesSolute carrier family 12

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-01-15.

Open TargetsGene–disease associations from the Open Targets Platform.