SLC6A3

Gene

solute carrier family 6 member 3

HGNCHGNC:11049 EnsemblENSG00000142319 NCBI Gene6531

Locus: gene with protein productLocation: 5p15.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium-dependent dopamine transporterQ01959

Protein · therapeutic target

Clinically validated target · 28 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDAT1 · DAT

View full nomenclature history (7)

Previous symbolsDAT1

Alias symbolsDAT

Previous namessolute carrier family 6 (neurotransmitter transporter, dopamine), member 3, dopamine transporter 1, solute carrier family 6 (neurotransmitter transporter), member 3

Alias namesdopamine transporter, Sodium-dependent dopamine transporter

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Infantile dystonia-parkinsonism

Classic dopamine transporter deficiency syndrome

Parkinsonism-dystonia, infantile

Attention Deficit Disorder with Hyperactivity

Major depressive disorder

Alzheimer's Disease

Obesity disorder

Sleep disorder

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Solute carrier family 6

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.