SLX1A

Gene

structure-specific endonuclease subunit SLX1A

HGNCHGNC:20922 EnsemblENSG00000132207 NCBI Gene548593

Locus: gene with protein productLocation: 16p11.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGIYD1

View full nomenclature history (4)

Previous symbolsGIYD1

Previous namesSLX1 homolog A, structure-specific endonuclease subunit, GIY-YIG domain containing 1, SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic central nervous system malformation

Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus

lissencephaly due to TUBA1A mutation

Polymicrogyria due to TUBB2B mutation

Leukoencephalopathies

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

GIY-YIG endonuclease domain containingProteins encoded by multiple genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-07-02.

Open TargetsGene–disease associations from the Open Targets Platform.