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SLX1B

Gene

structure-specific endonuclease subunit SLX1B

HGNCHGNC:28748EnsemblENSG00000181625NCBI Gene79008
Locus: gene with protein productLocation: 16p11.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGIYD2 · MGC5178
View full nomenclature history (5)
Previous symbolsGIYD2
Alias symbolsMGC5178
Previous namesSLX1 homolog B, structure-specific endonuclease subunit, GIY-YIG domain containing 2, SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic central nervous system malformation
Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus
lissencephaly due to TUBA1A mutation
Polymicrogyria due to TUBB2B mutation
Leukoencephalopathies

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

GIY-YIG endonuclease domain containingProteins encoded by multiple genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-07-02.
Open TargetsGene–disease associations from the Open Targets Platform.