SNAP25

Gene

synaptosome associated protein 25

HGNCHGNC:11132 EnsemblENSG00000132639 NCBI Gene6616

Locus: gene with protein productLocation: 20p12.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Synaptosomal-associated protein 25P60880

Protein · therapeutic target

Clinically validated target · 6 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSNAP · SNAP-25 · RIC-4 · RIC4 · SEC9 · bA416N4.2 · dJ1068F16.2

View full nomenclature history (9)

Previous symbolsSNAP

Alias symbolsSNAP-25, RIC-4, RIC4, SEC9, bA416N4.2, dJ1068F16.2

Previous namessynaptosomal-associated protein, 25kDa

Alias namesresistance to inhibitors of cholinesterase 4 homolog

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Congenital myasthenic syndromes

Migraine Disorders

Botulism

Genetic developmental and epileptic encephalopathy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SNAREs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.