SORL1

Gene

sortilin related receptor 1

HGNCHGNC:11185 EnsemblENSG00000137642 NCBI Gene6653

Locus: gene with protein productLocation: 11q24.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC11orf32 · gp250 · LR11 · LRP9 · SorLA · SorLA-1

View full nomenclature history (9)

Previous symbolsC11orf32

Alias symbolsgp250, LR11, LRP9, SorLA, SorLA-1

Previous nameschromosome 11 open reading frame 32, sortilin-related receptor, L(DLR class) A repeats-containing

Alias namesLDLR relative with 11 ligand-binding repeats

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Alzheimer's Disease

Dementia

Neurodegenerative Diseases

Smoking initiation

Liver Diseases

Marijuana Abuse

late-onset Alzheimers disease

Wet macular degeneration

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Fibronectin type III domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.