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SOS1

Gene

SOS Ras/Rac guanine nucleotide exchange factor 1

HGNCHGNC:11187EnsemblENSG00000115904NCBI Gene6654
Locus: gene with protein productLocation: 2p22.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGINGF · HGF · GF1
View full nomenclature history (5)
Previous symbolsGINGF
Alias symbolsHGF, GF1
Previous namesgingival fibromatosis, hereditary, 1, son of sevenless homolog 1 (Drosophila)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Noonan syndrome
RASopathy
Neoplasms
Bone development disease
Noonan syndrome 3
Hypertension
Endometrial Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingDbl family Rho GEFs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.