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SOX3

Gene

SRY-box transcription factor 3

HGNCHGNC:11199EnsemblENSG00000134595NCBI Gene6658
Locus: gene with protein productLocation: Xq27.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPHP
View full nomenclature history (4)
Previous symbolsPHP
Previous namespanhypopituitarism, SRY (sex determining region Y)-box 3, SRY-box 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Non-acquired isolated growth hormone deficiency
Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SRY-box transcription factors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.