Back to discover

SPARC

Gene

secreted protein acidic and cysteine rich

HGNCHGNC:11219EnsemblENSG00000113140NCBI Gene6678
Locus: gene with protein productLocation: 5q33.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asON · ONT · BM-40
View full nomenclature history (6)
Previous symbolsON
Alias symbolsONT, BM-40
Previous namesosteonectin
Alias namessecreted protein acidic and rich in cysteine, cysteine-rich protein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Osteogenesis Imperfecta
Neurodegenerative Diseases
Genetic Diseases, Inborn
Pre-Eclampsia
Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SPARC familySecretory calcium-binding phosphoprotein family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.