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SPTLC2

Gene

serine palmitoyltransferase long chain base subunit 2

HGNCHGNC:11278EnsemblENSG00000100596NCBI Gene9517
Locus: gene with protein productLocation: 14q24.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA0526 · LCB2 · LCB2A · hLCB2a
View full nomenclature history (4)
Alias symbolsKIAA0526, LCB2, LCB2A, hLCB2a

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Charcot-Marie-Tooth Disease
Amyotrophic Lateral Sclerosis
Alzheimer's Disease
Hereditary sensory and autonomic neuropathy
Parkinson's Disease
Multiple Sclerosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Serine palmitoyltransferase long chain base subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.