SRC

Gene

SRC proto-oncogene, non-receptor tyrosine kinase

HGNCHGNC:11283 EnsemblENSG00000197122 NCBI Gene6714

Locus: gene with protein productLocation: 20q11.23

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Proto-oncogene tyrosine-protein kinase SrcP12931

Protein · therapeutic target

Clinically validated target · 4 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSRC1 · c-src · ASV

View full nomenclature history (4)

Previous symbolsSRC1

Alias symbolsc-src, ASV

Previous namesv-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms

chronic myelogenous leukemia, BCR-ABL1 positive

Actinic keratosis

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Medullary thyroid gland carcinoma

Noonan syndrome

Costello syndrome

Rare hemorrhagic disorder due to a constitutional platelet anomaly

Cardiomyopathy, Hypertrophic

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SH2 domain containingSrc family tyrosine kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.