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SYNE2

Gene

spectrin repeat containing nuclear envelope protein 2

HGNCHGNC:17084EnsemblENSG00000054654NCBI Gene23224
Locus: gene with protein productLocation: 14q23.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSYNE-2 · DKFZP434H2235 · Nesprin-2 · NUANCE · NUA · KIAA1011 · Nesp2
View full nomenclature history (10)
Alias symbolsSYNE-2, DKFZP434H2235, Nesprin-2, NUANCE, NUA, KIAA1011, Nesp2
Previous namesspectrin repeat containing, nuclear envelope 2
Alias namesnuclear envelope spectrin repeat-2, nucleus and actin connecting element

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Cutaneous melanoma
Hair color
Cerebral Palsy
Diabetes, Gestational
Atrial Fibrillation
Psoriasis
Heart Septal Defects, Ventricular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Spectrin repeat containing nuclear envelope familyKASH domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.