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TCF7L2

Gene

transcription factor 7 like 2

HGNCHGNC:11641EnsemblENSG00000148737NCBI Gene6934
Locus: gene with protein productLocation: 10q25.2-q25.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTCF4 · TCF-4
View full nomenclature history (3)
Previous symbolsTCF4
Alias symbolsTCF-4
Previous namestranscription factor 7-like 2 (T-cell specific, HMG-box)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes Mellitus, Type 2
Colorectal adenocarcinoma
Prostate carcinoma
Diabetes Mellitus
Breast Neoplasms
Myopia
Diabetes Mellitus, Type 1
Colonic Neoplasms
Coronary Artery Disease
Diabetes, Gestational

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

TCF/LEF transcription factor familyWnt enhanceosome complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.