TGFBR1

Gene

transforming growth factor beta receptor 1

HGNCHGNC:11772 EnsemblENSG00000106799 NCBI Gene7046

Locus: gene with protein productLocation: 9q22.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

TGF-beta receptor type-1P36897

Protein · therapeutic target

Clinical-stage target · 2 candidates in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMSSE · ESS1 · ALK-5 · ACVRLK4 · ALK5 · TBRI · TBR-i

View full nomenclature history (10)

Previous symbolsMSSE, ESS1

Alias symbolsALK-5, ACVRLK4, ALK5, TBRI, TBR-i

Previous namesmultiple self-healing squamous epithelioma, transforming growth factor beta receptor I

Alias namesactivin A receptor type II-like kinase, 53kDa

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Type 1 receptor serine/threonine kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.